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Adversity and Obstacle
abstruse, adversity, affliction, aggravate, ailing, arduous, autarky, besiege, challenging, chronic, claustrophobia, coarse, convolute, crucible, cumbersome, defect, deficiency, demanding, difficulty, dire, disqualify, disruptive, dodder, drudgery, dysfunctional, encumber, exacerbate, exasperate, faltering, finicky, flounder, gaslight, grueling, hamper, hapless, hinder, impede, impediment, implacable, incorrigible, indeterminate, inexplicable, inscrutable, insomnia, intensive, intractable, irreconcilable, laborious, menial, nebulous, obdurate, obfuscate, obscure, obstreperous, perfunctory, plight, precariat, precarious, privation, querulous, quixotic, recalcitrant, refractory, rout, scratchy, serious, siege, sortie, squalid, strife, stubborn, stymie, surly, toil, tolerate, totter, travail, tribulation, unapproachable, vague, vanquish, vendetta